S 33138

S33138 is a D3 receptor antagonist. S33138 inhibits addiction in animal models of addiction. S33138 reduces cognitive impairment in rodent and primate models of schizophrenia and Parkinson's disease. S33138 can be used in research on neurological disorders such as schizophrenia and Parkinson's disease[1][2].

Product Specifications

CAS Number

[245514-32-3]

UNSPSC

12352005

Target

Dopamine Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

CC(NC(C=C1)=CC=C1CCN2C[C@@H]3[C@@H](C2)COC4=CC=C(C#N)C=C43)=O

Molecular Formula

C22H23N3O2

Molecular Weight

361.44

References & Citations

[1]Peng XQ, et al.. The preferential dopamine D3 receptor antagonist S33138 inhibits cocaine reward and cocaine-triggered relapse to drug-seeking behavior in rats. Neuropharmacology. 2009 Mar;56 (4) :752-60. |[2]Millan MJ, et al. The dopamine D3 receptor antagonist, S33138, counters cognitive impairment in a range of rodent and primate procedures. Int J Neuropsychopharmacol. 2010 Sep;13 (8) :1035-51.