SMN-C3
SMN-C3 is an orally active SMN2 splicing modulator and has the potential to treat spinal muscular atrophy (SMA) .
Product Specifications
CAS Number
1449597-34-5
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/SMN-C3.html
Purity
99.53
Solubility
DMSO : 1.96 mg/mL (ultrasonic; warming; adjust pH to 5 with HCl; heat to 60°C)
Smiles
O=C1C=C(C2=NN3C(C(C)=NC(C)=C3)=C2)N=C4N1C=C(C5CCN(CC)CC5)C=C4C
Molecular Formula
C24H28N6O
Molecular Weight
416.52
Precautions
H315, H319, H320
References & Citations
[1]Naryshkin NA, et al. Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy. Science. 2014 Aug 8;345 (6197) :688-93.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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