TGF-βRI inhibitor 3

TGF-βRI inhibitor 3 (Compound 9ac) is a selective TGF-β inhibitor. TGF-βRI inhibitor 3 can effectively inhibit the TGF-β signaling pathway. TGF-βRI inhibitor 3 has IC50 values of 13 μM and 0.63 μM for c-Src kinase and ALK5 kinase, respectively[1].

Product Specifications

CAS Number

[666729-57-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Anaplastic lymphoma kinase (ALK) ; Src; TGF-β Receptor

Related Pathways

Protein Tyrosine Kinase/RTK; TGF-beta/Smad

Field of Research

Others

Purity

99.16

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C1=CC(C)=C(C)C=C1OC2=CC=NC3=CC(OC)=C(OC)C=C23)=O

Molecular Formula

C21H21NO4

Molecular Weight

351.40

Precautions

H302, H315, H319

References & Citations

[1]Shimizu T, et al. Synthesis and evaluation of [2- (4-quinolyloxy) phenyl]methanone derivatives: novel selective inhibitors of transforming growth factor-beta kinase. J Med Chem. 2008 Jun 12;51 (11) :3326-9.