Porfiromycin
Porfiromycin (N-Methylmitomycin C) is a bioreductive alkylating agent that preferentially kill hypoxic tumor cells relative to other aerobic counterparts[1].
Product Specifications
CAS Number
801-52-5
Product Name Alternative
N-Methylmitomycin C; NSC-56410; U-14743
UNSPSC
12352005
Target
DNA Alkylator/Crosslinker
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
CO[C@]12N(C[C@@]3([H])[C@]2([H])N3C)C4=C(C(C(N)=C(C4=O)C)=O)[C@H]1COC(N)=O
Molecular Formula
C16H20N4O5
Molecular Weight
348.35
References & Citations
[1]Keyes SR, Rockwell S, Sartorelli AC. Porfiromycin as a bioreductive alkylating agent with selective toxicity to hypoxic EMT6 tumor cells in vivo and in vitro. Cancer Res. 1985;45 (8) :3642-3645.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
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