INH2BP

INH2BP is a poly (ADP-ribose) polymerase (PARP) inhibitor with antioxidant and anti-apoptotic activities. INH2BP reduces the production of intracellular reactive oxygen species (ROS), modulates the expression of apoptosis-related proteins such as Bax, Bcl-2 and cleaved caspase-3 and enhances cell survival through the activation of the ERK1/2 and p38 MAPK signaling pathways. INH2BP is promising for research of cardiovascular diseases[1].

Product Specifications

CAS Number

[137881-27-7]

Product Name Alternative

6-aMino-5-IodocouMarin

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Bcl-2 Family; Caspase; ERK; p38 MAPK; PARP; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Cardiovascular Disease

Smiles

O=C1C=CC2=C(I)C(N)=CC=C2O1

Molecular Formula

C9H6INO2

Molecular Weight

287.05

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501

References & Citations

[1]Back OC, et al. The Protective Effect of INH2BP, a Novel PARP Inhibitor 5-Iodo-6-Amino-1,2-Benzopyrone, Against Hydrogen Peroxide-Induced Apoptosis Through ERK and p38 MAPK in H9c2 Cells. Pharmacology. 2015;96 (5-6) :259-70.