INH2BP
INH2BP is a poly (ADP-ribose) polymerase (PARP) inhibitor with antioxidant and anti-apoptotic activities. INH2BP reduces the production of intracellular reactive oxygen species (ROS), modulates the expression of apoptosis-related proteins such as Bax, Bcl-2 and cleaved caspase-3 and enhances cell survival through the activation of the ERK1/2 and p38 MAPK signaling pathways. INH2BP is promising for research of cardiovascular diseases[1].
Product Specifications
CAS Number
137881-27-7
Product Name Alternative
6-aMino-5-IodocouMarin
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Bcl-2 Family; Caspase; ERK; p38 MAPK; PARP; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Cardiovascular Disease
Smiles
O=C1C=CC2=C(I)C(N)=CC=C2O1
Molecular Formula
C9H6INO2
Molecular Weight
287.05
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Isoform
Caspase 3; ERK1; ERK2; p38 MAPK
Frequently Asked Questions
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