Indibulin (Standard)
Indibulin (Standard) is the analytical standard of Indibulin. This product is intended for research and analytical applications. Indibulin (ZIO 301), an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neurotoxicity. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis[1].
Product Specifications
CAS Number
204205-90-3
UNSPSC
12352100
Target
Apoptosis; Microtubule/Tubulin; Reference Standards
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Others
Field of Research
Cancer; Neurological Disease
Smiles
O=C(NC1=CC=NC=C1)C(C2=CN(CC3=CC=C(Cl)C=C3)C4=C2C=CC=C4)=O
Molecular Formula
C22H16ClN3O2
Molecular Weight
389.83
References & Citations
[1]Kapoor S, et al. Indibulin dampens microtubule dynamics and produces synergistic antiproliferative effect with vinblastine in MCF-7 cells: Implications in cancer chemotherapy. Sci Rep. 2018 Aug 17;8 (1) :12363.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Frequently Asked Questions
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