ND-654
ND-654 is a highly selective acetyl-CoA carboxylase (ACC) inhibitor (IC50: ACC1=3 nM, ACC2=8 nM) . ND-654 reduces hepatic lipogenesis, decreases neutrophil recruitment and promotes anti-inflammatory M2 macrophage polarization. ND-654 is promising for research of nonalcoholic steatohepatitis and hepatocellular carcinoma[1].
Product Specifications
CAS Number
1434641-55-0
UNSPSC
12352005
Target
Acetyl-CoA Carboxylase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Metabolic Disease
Smiles
CC(C)(N(C(N(C[C@H](O[C@H]1CC[C@@H](O)CC1)C2=CC=CC=C2OC)C3=C4C(C)=C(C5=NC=CO5)S3)=O)C4=O)C(O)=O
Molecular Formula
C29H33N3O8S
Molecular Weight
583.65
References & Citations
[1]Lally JSV, et al. Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma. Cell Metab. 2019 Jan 8;29 (1) :174-182.e5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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