Seliforant
Seliforant (SENS-111) is a selective and orally histamine H4 receptor antagonist.
Product Specifications
CAS Number
1164115-89-2
Product Name Alternative
SENS-111
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/seliforant.html
Purity
95.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CNC1CN(C2=NC(CC(C)C)=NC(N)=C2)C1
Molecular Formula
C12H21N5
Molecular Weight
235.33
References & Citations
[1]Petremann M, Gueguen C, Delgado Betancourt V, Wersinger E, Dyhrfjeld-Johnsen J. Effect of the novel histamine H4 receptor antagonist SENS-111 on spontaneous nystagmus in a rat model of acute unilateral vestibular loss. Br J Pharmacol. 2020;177 (3) :623-633. |[2]Venail F, Attali P, Wersinger E, Gomeni R, Poli S, Schmerber S. Safety, tolerability, pharmacokinetics and pharmacokinetic-pharmacodynamic modelling of the novel H4 receptor inhibitor SENS-111 using a modified caloric test in healthy subjects. Br J Clin Pharmacol. 2018;84 (12) :2836-2848.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
H4 Receptor
Available Sizes
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