TOP1362

TOP1362 is a narrow spectrum kinase inhibitor. TOP1362 is a potent inhibitor of P38-α and Syk kinases with Kd values of 26 and 18 nM, respectively and an IC50 of 14 nM in the Src kinase activity assay. TOP1362 potently inhibits P38-α, Src and Syk. TOP1362 can be used in the research of dry eye syndrome[1].

Product Specifications

CAS Number

[1630203-25-6]

UNSPSC

12352005

Target

P38 MAPK; Src; Syk

Related Pathways

MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK

Field of Research

Neurological Disease

Smiles

O=C(NCCCN1CCOCC1)C2=CC(OC)=CC(NC3=NC=CC(OC4=C5C=CC=CC5=C(NC(NC6=CC(C(C)(C)C)=CC(NS(=O)(C)=O)=C6OC)=O)C=C4)=C3)=C2

Molecular Formula

C43H51N7O8S

Molecular Weight

825.97

References & Citations

[1]Hagan S, et al. Narrow Spectrum Kinase Inhibitor (NSKI) Targets Are Up-regulated in Conjunctival Cells from Dry Eye Patients Compared to Healthy Controls[J]. Investigative Ophthalmology & Visual Science, 2017, 58 (8) : 464-464.