TOP1362
TOP1362 is a narrow spectrum kinase inhibitor. TOP1362 is a potent inhibitor of P38-α and Syk kinases with Kd values of 26 and 18 nM, respectively and an IC50 of 14 nM in the Src kinase activity assay. TOP1362 potently inhibits P38-α, Src and Syk. TOP1362 can be used in the research of dry eye syndrome[1].
Product Specifications
CAS Number
1630203-25-6
UNSPSC
12352005
Target
P38 MAPK; Src; Syk
Related Pathways
MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Field of Research
Neurological Disease
Smiles
O=C(NCCCN1CCOCC1)C2=CC(OC)=CC(NC3=NC=CC(OC4=C5C=CC=CC5=C(NC(NC6=CC(C(C)(C)C)=CC(NS(=O)(C)=O)=C6OC)=O)C=C4)=C3)=C2
Molecular Formula
C43H51N7O8S
Molecular Weight
825.97
References & Citations
[1]Hagan S, et al. Narrow Spectrum Kinase Inhibitor (NSKI) Targets Are Up-regulated in Conjunctival Cells from Dry Eye Patients Compared to Healthy Controls[J]. Investigative Ophthalmology & Visual Science, 2017, 58 (8) : 464-464.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P38α
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