Eicosatetraynoic acid

Eicosatetraynoic acid (ETYA) is a nonspecific inhibitor of cyclooxygenase and lipoxygenase (ID50=8 μM and 4 μM, respectively) [1]. Eicosatetraynoic acid (ETYA) activates PPARα and PPARγ chimeras at 10 μM[2]. Eicosatetraynoic acid specifically interferes with the replication of the cowpox virus both in vivo and in vitro[3]. Eicosatetraynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[1191-85-1]

Product Name Alternative

ETYA

UNSPSC

12352211

Target

COX; Orthopoxvirus; PPAR

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Others

Purity

99.9

Solubility

DMSO : 2 mg/mL (ultrasonic) |Ethanol : < 1 mg/mL

Smiles

CCCCCC#CCC#CCC#CCC#CCCCC(O)=O

Molecular Formula

C20H24O2

Molecular Weight

296.40

References & Citations

[1]Hammarström S, et al. Selective inhibition of platelet n-8 lipoxygenase by 5,8,11-eicosatriynoic acid. Biochim Biophys Acta. 1977 Jun 22;487 (3) :517-9.|[2]Kliewer SA, et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell. 1995 Dec 1;83 (5) :813-9.|[3]Palumbo GJ, et, al. Inhibitors of the lipoxygenase pathway specifically block orthopoxvirus replication. Virology. 1991 Jan;180 (1) :457-63.