KW-2581
KW-2581 is a steroidal selective steroid sulfatase (STS) inhibitor with an IC50 of 4 nM. KW-2581 inhibits STS activity of ZR-75-1 cells with an IC50 of 13 nM. KW-2581 inhibits the E1S-stimulated growth of ZR-75-1 cells with an IC50 of 0.18 nM. KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells both in vitro and in vivo. KW-2581 induced regression in E1S-induced tumor growth. KW-2581 can be studied in research on hormone receptors-positive breast cancer[1][2].
Product Specifications
CAS Number
284045-56-3
UNSPSC
12352005
Target
Steroid Sulfatase
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=S(OC1=CC=C2[C@@]3([H])CC[C@]4(C)C(C(N(C(C)C)C(C)C)=O)=CC[C@@]4([H])[C@]3([H])CCC2=C1)(N)=O
Molecular Formula
C25H36N2O4S
Molecular Weight
460.63
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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