Folinic acid
Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (HY-14519) as a rescue agent to decrease MTX-induced toxicity[1].
Product Specifications
CAS Number
[58-05-9]
Product Name Alternative
Leucovorin
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antifolate; Endogenous Metabolite
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/folinic-acid.html
Purity
99.98
Solubility
DMSO : 175 mg/mL (ultrasonic)
Smiles
O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2N(C=O)C3=C(N=C(N)NC3=O)NC2)C=C1)=O
Molecular Formula
C20H23N7O7
Molecular Weight
473.44
Precautions
H302, H315, H319, H335
References & Citations
[1]Keshava, C., et al., Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res, 1998. 397 (2) : p. 221-8.|[2]Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92 (12) :1438-44.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Human Endogenous Metabolite
Citation 01
Appl Microbiol Biotechnol. 2024 Dec;108 (1) :1-15.|bioRxiv. 2023 Feb 28.|bioRxiv. 2025 Sep 17.|Int J Immunopathol Pharmacol. 2025 Jan-Dec:39:3946320251338662.|JAMA Oncol. 2022 Jan 1;8 (1) :e215445.|Mol Oncol. 2020 Nov;14 (11) :2894-2919.|NPJ Precis Oncol. 2023 Dec 8;7 (1) :128.|Patent. US20230101335A1.|Virology. 2023 Aug:585:205-214.|EBioMedicine. 2024 Apr:102:105041.|J Mol Med (Berl) . 2019 Aug;97 (8) :1183-1193.|Nat Commun. 2020 Apr 14;11 (1) :1792.|J Mol Med (Berl) . 2019 Aug;97 (8) :1183-1193.
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