Folinic acid
Product Specifications
UNSPSC Description
Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity[1].
Target Antigen
Antifolate; Endogenous Metabolite
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/folinic-acid.html
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2N(C=O)C3=C(N=C(N)NC3=O)NC2)C=C1)=O
Molecular Weight
473.44
References & Citations
[1]Keshava, C., et al., Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res, 1998. 397(2): p. 221-8.|[2]Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92(12):1438-44.Appl Microbiol Biotechnol. 2024 Dec;108(1):1-15.|bioRxiv. 2023 Feb 28.|JAMA Oncol. 2022 Jan 1;8(1):e215445.|Mol Oncol. 2020 Nov;14(11):2894-2919.|NPJ Precis Oncol. 2023 Dec 8;7(1):128.|Patent. US20230101335A1.|Virology. 2023 Jun 21.|EBioMedicine. 2024 Mar 13:102:105041.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.|Nat Commun. 2020 Apr 14;11(1):1792.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-17556/Folinic-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-17556/Folinic-acid-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
58-05-9
Available Sizes
Curated Selection
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