Hydrazinocurcumin
Hydrazinocurcumin (Curcumin pyrazole) is a potent endothelial cell proliferation inhibitor (IC50=520 nM) . Hydrazinocurcumin disrupts angiogenic signaling pathways and inhibits endothelial cell migration and tube formation, exerting anti-angiogenic activity. Hydrazinocurcumin is promising for research of tumor angiogenesis inhibition, metastatic cancer, and vascular-dependent diseases such as retinopathies[1].
Product Specifications
CAS Number
[131068-23-0]
Product Name Alternative
Curcumin pyrazole
UNSPSC
12352005
Target
Others
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
OC1=CC=C(/C=C/C2=NNC(/C=C/C3=CC=C(O)C(OC)=C3)=C2)C=C1OC
Molecular Formula
C21H20N2O4
Molecular Weight
364.39
References & Citations
[1]Shim JS, et al. Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferation. Bioorg Med Chem. 2002 Sep;10 (9) :2987-92.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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