Anacetrapib (Standard)
Anacetrapib (Standard) is the analytical standard of Anacetrapib. This product is intended for research and analytical applications. Anacetrapib is a potent CETP inhibitor, with IC50s of 7.9±2.5 nM and 11.8±1.9 nM for rhCETP and C13S CETP mutant, respectively.
Product Specifications
CAS Number
[875446-37-0]
UNSPSC
12352100
Target
PCSK9; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cardiovascular Disease
Smiles
O=C1O[C@@H]([C@@H](N1CC2=CC(C(F)(F)F)=CC=C2C3=CC(C(C)C)=C(C=C3OC)F)C)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4
Molecular Formula
C30H25F10NO3
Molecular Weight
637.51
References & Citations
[1]Niesor EJ, et al. Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport. J Lipid Res. 2010, 51 (12), 3443-3454.|[2]Dong B, et al. CETP inhibitors downregulate hepatic LDL receptor and PCSK9 expression in vitro and in vivo through a SREBP2 dependent mechanism. Atherosclerosis. 2014 Aug;235 (2) :449-62.|[3]Tan EY, et al. Pharmacokinetics, metabolism, and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in rats and rhesus monkeys. Drug Metab Dispos. 2010, 38 (3), 459-473.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12090R/
Scientific Category
Reference Standards
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
GTR15093111 1 Vial
Lentiviral human KLRC4 shRNA (UAS) - Lentiviral human KLRC4 shRNA (UAS, iRFP) (100)
Ask
View Details 
MBS1261474-01 0.02 mg (E-Coli)
Recombinant Bacillus subtilis Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha (acoA)
Ask
View Details MBS1261474-02 0.02 mg (Yeast)
Recombinant Bacillus subtilis Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha (acoA)
Ask
View Details 
MBS1261474-03 0.1 mg (E-Coli)
Recombinant Bacillus subtilis Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha (acoA)
Ask
View Details MBS1261474-04 0.1 mg (Yeast)
Recombinant Bacillus subtilis Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha (acoA)
Ask
View Details MBS1261474-05 0.02 mg (Baculovirus)
Recombinant Bacillus subtilis Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha (acoA)
Ask
View Details