DZ-2384
DZ-2384 is a potent microtubule-targeting agent. DZ-2384 increases the rescue frequency and preserves the microtubule network in nonmitotic cells and primary neurons. DZ-2384 acts synergistically with anti-CTLA-4 immunotherapy in Taxane-sensitive and Taxane-resistant xenograft murine models of triple-negative breast cancer (TNBC) . DZ-2384 exhibits potent antitumor activity in adult acute lymphocytic leukemia (ALL) models. DZ-2384 can be used for cancer research, such as TNBC and ALL[1][2].
Product Specifications
CAS Number
1403850-91-8
UNSPSC
12352005
Target
Microtubule/Tubulin
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
FC1=CC=C2C([C@@]34C5=C(C6=NC(CO)=CO6)N=C([C@@H](NC([C@@H](NC([C@@H](O)C(C)C)=O)CC7=CC=C(O[C@@]4([H])N2)C3=C7)=O)C(C)(C)C)O5)=C1
Molecular Formula
C34H36FN5O7
Molecular Weight
645.68
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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