AKI-001
AKI-001 is an prototype pentacyclic inhibitor of aurora kinase with cellular potency of IC50 of less than 100 nM. AKI-001 shows low nanomolar potency against Aurora A and Aurora B enzymes[1].
Product Specifications
CAS Number
[925218-37-7]
UNSPSC
12352005
Target
Aurora Kinase
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C1C(C)(C)C2=CC3=C(C=C2N1CC)C(CCCC4=C(C)NN=C45)=C5N3
Molecular Formula
C21H24N4O
Molecular Weight
348.44
References & Citations
[1]Rawson, T. E., et al., (2008) . A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability. Journal of medicinal chemistry, 51 (15), 4465-4475.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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