VUF11207 (TFA)

VUF11207 (Compound 29) TFA is a CXCR7 agonist (pKi of 8.1) that induces recruitment of β-arrestin2 (pEC50 of 8.8) and subsequent internalization (pEC50 of 7.9) of CXCR7[1].

Product Specifications

CAS Number

[1492153-74-8]

UNSPSC

12352005

Target

CXCR

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Field of Research

Endocrinology

Solubility

10 mM in DMSO

Smiles

O=C(N(C/C(C)=C/C1=CC=CC=C1F)CCC2N(C)CCC2)C3=CC(OC)=C(OC)C(OC)=C3.FC(C(O)=O)(F)F

Molecular Formula

C29H36F4N2O6

Molecular Weight

584.60

References & Citations

[1]Wijtmans M, et al. Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists. Eur J Med Chem. 2012 May;51:184-92.