Avenanthramide A-d4
Avenanthramide A-d4 is the deuterium labeled Avenanthramide A. Avenanthramide A is a phytoalexin, which can be found in oats (Avena sativa L.). Avenanthramide A targets the RNA helicase DDX3, leads to mitochondrial swelling and increased ROS production, and induces apoptosis in CRC cells. Avenanthramide A exhibits antitumor efficacy in mouse model. Avenanthramide A orally active[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Isotope-Labeled Compounds; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others
Field of Research
Cancer
Smiles
O=C(C1=CC(O)=CC=C1NC(/C=C/C2=C([2H])C([2H])=C(C([2H])=C2[2H])O)=O)O
Molecular Formula
C16H9D4NO5
Molecular Weight
303.30
References & Citations
[1]Fu R, et al., Avenanthramide A triggers potent ROS-mediated anti-tumor effects in colorectal cancer by directly targeting DDX3. Cell Death Dis. 2019 Aug 7;10 (8) :593.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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