AD-5075

AD-5075 is an orally active insulin sensitizer. AD-5075 mediates its antidiabetic activity by binding to PPARγ and thereby generating an active conformation of the receptor[1].

Product Specifications

CAS Number

[103788-05-2]

UNSPSC

12352005

Target

PPAR

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Smiles

O=C(SC1CC2=CC=C(C=C2)OCC(C3=C(OC(C4=CC=CC=C4)=N3)C)O)NC1=O

Molecular Formula

C22H20N2O5S

Molecular Weight

424.47

References & Citations

[1]Berger J, et al. Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-gamma: binding and activation correlate with antidiabetic actions in db/db mice[J]. Endocrinology, 1996, 137 (10) : 4189-4195.