AkaLumine

AkaLumine is a D-luciferin (HY-12591A) analogue with a Km of 2.06 μM for recombinant firefly luciferase (Fluc) protein. AkaLumine emits near-infrared (NIR) light (λmax=677 nm) in reactions with native Fluc. AkaLumine has high tissue-penetration and increases detection sensitivity from deep-tissue targets[1].

Product Specifications

CAS Number

[1176235-08-7]

UNSPSC

12171500

Hazard Statement

H302-H315-H319-H335

Target

Fluorescent Dye

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Solubility

10 mM in H2O

Smiles

O=C([C@@H]1N=C(/C=C/C=C/C2=CC=C(N(C)C)C=C2)SC1)O

Molecular Formula

C16H18N2O2S

Molecular Weight

302.39

Precautions

P261-P280-P302+P352

References & Citations

[1]Kuchimaru T, et al. A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging. Nat Commun. 2016 Jun 14;7:11856. |[2]Zhou M, et al. Generation of an Akaluc knock-in human embryonic stem cell reporter line using CRISPR-Cas9 technology. Stem Cell Res. 2021 Oct;56:102532.