2-Cyanoethylalsterpaullone

2-Cyanoethylalsterpaullone (compound 7) is an Alsterpaullone (HY-108359) derivative, which exhibits potent and selective inhibitory activities against CDK1/Cyclin B and GSK-3β (GSK-3β: IC50=0.8 nM; CDK1/Cyclin B: IC50=0.23 nM) [1].

Product Specifications

CAS Number

[852527-97-0]

UNSPSC

12352005

Target

CDK; GSK-3

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Stem Cell/Wnt

Field of Research

Cancer

Smiles

N#CCCC1=CC=C(NC(CC2=C3NC4=C2C=C([N+]([O-])=O)C=C4)=O)C3=C1

Molecular Formula

C19H14N4O3

Molecular Weight

346.34

References & Citations

[1]Kunick, et al. "Structure‐aided optimization of kinase inhibitors derived from alsterpaullone." ChemBioChem 6.3 (2005) : 541-549.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK1; GSK-3β

Curated Selection

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