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EPHA4 antagonist-1

EPHA4 antagonist-1 (Compound 2) is an EphA4 receptor antagonist. EPHA4 antagonist-1 is also an EphA2 receptor antagonist. EPHA4 antagonist-1 inhibits ephrin-A5 AP binding to EphA4 Fc receptor, with an IC50 of 10 μM[1].

Product Specifications

CAS Number

[313701-92-7]

UNSPSC

12352005

Hazard Statement

H315-H317-H318

Target

Ephrin Receptor

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C(C1=CC(N2C(C)=CC=C2C)=CC=C1O)O

Molecular Formula

C13H13NO3

Molecular Weight

231.25

Precautions

P261-P264-P272-P280-P302+P352-P362+P364-P501

References & Citations

[1]Noberini R, et al. A disalicylic acid-furanyl derivative inhibits ephrin binding to a subset of Eph receptors. Chem Biol Drug Des. 2011 Oct;78 (4) :667-78.

Shipping Conditions

Room temperature

Scientific Category

Reference compound2

Clinical Information

No Development Reported

Isoform

EphA

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