EPHA4 antagonist-1
EPHA4 antagonist-1 (Compound 2) is an EphA4 receptor antagonist. EPHA4 antagonist-1 is also an EphA2 receptor antagonist. EPHA4 antagonist-1 inhibits ephrin-A5 AP binding to EphA4 Fc receptor, with an IC50 of 10 μM[1].
Product Specifications
CAS Number
[313701-92-7]
UNSPSC
12352005
Hazard Statement
H315-H317-H318
Target
Ephrin Receptor
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(C1=CC(N2C(C)=CC=C2C)=CC=C1O)O
Molecular Formula
C13H13NO3
Molecular Weight
231.25
Precautions
P261-P264-P272-P280-P302+P352-P362+P364-P501
References & Citations
[1]Noberini R, et al. A disalicylic acid-furanyl derivative inhibits ephrin binding to a subset of Eph receptors. Chem Biol Drug Des. 2011 Oct;78 (4) :667-78.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Isoform
EphA
Curated Selection
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