8-OH-DPAT (Standard)
8-OH-DPAT (Standard) is the analytical standard of 8-OH-DPAT. This product is intended for research and analytical applications. 8-OH-DPAT is a potent and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A and a Ki of 466 nM for 5-HT7; 8-OH-DPAT weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5) .
Product Specifications
CAS Number
78950-78-4
UNSPSC
12352100
Target
5-HT Receptor; Reference Standards
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
OC1=C2CC(N(CCC)CCC)CCC2=CC=C1
Molecular Formula
C16H25NO
Molecular Weight
247.38
References & Citations
[1]DEREK N. MIDDLEMISS, et al. 8-HYDROXY-2- (DI-n-PROPYLAMINO) -TETRALIN DISCRIMINATES BETWEEN SUBTYPES OF|[2]Bard JA, et al. Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. J Biol Chem. 1993 Nov 5;268 (31) :23422-6.|[3]Mori T, et al. Narcolepsy-like sleep disturbance in orexin knockout mice are normalized by the 5-HT1A receptor agonist 8-OH-DPAT. Psychopharmacology (Berl) . 2016 Jun;233 (12) :2343-53.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Frequently Asked Questions
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