Recombinant Human/Mouse/Rat BDNF Protein
Product Specifications
Background
Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF; NT-3 and NT-4; BDNF binds with high affinity to the TrkB kinase receptor. It also binds with the LNGFR (for low-affinity nerve growth factor receptor; also known as p75) . BDNF promotes the survival; growth and differentiation of neurons. It serves as a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. BDNF expression is altered in neurodegenerative disorders such as Parkinson' s and Alzheimer' s disease.
Abbreviation
BDNF
Synonyms
Abrineurin; BDNF; Brain-Derived Neurotrophic Factor
UniProt
P23560
Accession Number
P23560
Expression System
E.coli
Tag
C-His
Sequence
His129-Arg247
Applications
Cell culture
Field of Research
Cardiovascular; Neuroscience; metabolism
Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method.
Purity
> 98 % as determined by reducing SDS-PAGE.
Bioactivity
50
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
14.5 kDa
Observed Molecular Weight
14 kDa
Species
Human/Mouse/Rat
Available Sizes
Documents
Frequently Asked Questions
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