(S) -Padsevonil

(S) -Padsevonil is the S-enantiomer of Padsevonil (HY-109009) .Padsevonil (UCB0942) is a potent antiepileptic agent that selectively acts on presynaptic and postsynaptic targets. Padsevonil binds to synaptic vesicular protein 2 (SV2) with high affinity. Padsevonil is also a positive allosteric modulator and partial agonist of GABAAR, with high potency against α1 and α5 receptors. Padsevonil has antiepileptic effects in a variety of rodent models[1][2].

Product Specifications

CAS Number

[1294001-37-8]

Product Name Alternative

(S) -UCB-0942

UNSPSC

12352005

Target

GABA Receptor

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Purity

99.40

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C1N(C[C@H](CC(F)(F)Cl)C1)CC(N(N=C(COC)S2)C2=N3)=C3C(F)(F)F

Molecular Formula

C14H14ClF5N4O2S

Molecular Weight

432.80

References & Citations

[1]Niespodziany I, et al. Functional characterization of the antiepileptic drug candidate, padsevonil, on GABAA receptors. Epilepsia. 2020 May;61 (5) :914-923.|[2]Leclercq K, et al. Pharmacological Profile of the Novel Antiepileptic Drug Candidate Padsevonil: Characterization in Rodent Seizure and Epilepsy Models. J Pharmacol Exp Ther. 2020 Jan;372 (1) :11-20.