What is the catalog number for ICG-001?

The catalog number for ICG-001 is SIH-387-5MG.

What sizes are available for ICG-001?

ICG-001 is available in the following size(s): 5 mg.

ICG-001 is currently made to order / not held in immediate stock. Contact us for lead time.

ICG-001

β-catenin inhibitor

Product Specifications

Background

Inhibitor of TCF/β-catenin-mediated transcription. Selectively inhibits β-catenin/CBP interaction; displays no effect on β-catenin/p300 interaction. Exhibits growth inhibitory effects in colon carcinoma cell lines (SW480 and HCT-116 cells); also displays efficacy in Min mouse and nude mouse SW620 xenograft models.

CAS Number

847591-62-2

Product Name Alternative

(6S,9aS) -Hexahydro-6-[ (4-hydroxyphenyl) methyl]-8- (1-naphthalenylmethyl) -4,7-dioxo-N- (phenylmethyl) -2H-pyrazino[1,2-a]pyrimidine-1 (6H) -carboxamide

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Cell Signaling

Purity

>98%

Weight

0.005

Format

White solid

Solubility

Soluble to 100 mM in DMSO and to 50 mM in ethanol

Molecular Formula

C33H32N4O4

Molecular Weight

548.63

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Emami K.H., et al. (2004) Proc. Natl. Acad. Sci. USA. 101(34): 12682-7. 2. De Sousa E.M., et al. (2011) Clin. Cancer Res. 17(4): 647-53. 3. Zhou B., et al. (2012) J. Biol. Chem. 287(10): 7026-38.