Pridopidine (Standard)

Pridopidine (Standard) is the analytical standard of Pridopidine. This product is intended for research and analytical applications. Pridopidine, a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist. Pridopidine exerts high affinity towards sigma 1 receptor (S1R) with Ki between 70 and 80 nM, which is ~100x higher than its affinity toward D2R.

Product Specifications

CAS Number

[346688-38-8]

UNSPSC

12352100

Target

Dopamine Receptor; Reference Standards

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

O=S(C1=CC(C2CCN(CCC)CC2)=CC=C1)(C)=O

Molecular Formula

C15H23NO2S

Molecular Weight

281.41

References & Citations

[1]Geva M, et al. Pridopidine activates neuroprotective pathways impaired in Huntington Disease. Hum Mol Genet. 2016 Sep 15;25 (18) :3975-3987.|[2]Squitieri F, et al. Pridopidine, a dopamine stabilizer, improves motor performance and shows neuroprotective effects in Huntington disease R6/2 mouse J Cell Mol Med. 2015 Nov;19 (11) :2540-8. model.