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Nemazoline (hydrochloride)

Nemazoline hydrochloride (A-57219 hydrochloride) is selective α-adrenergic agent with α1-agonist/α2-antagonist activity, which is used as a nasal decongestant. Nemazoline hydrochloride produces decongestion by α1-mediated contraction of capacitance vessels, but not compromises blood flow by virtue of α2-antagonism. Nemazoline hydrochloride also blocks endogenous noradrenaline-mediated α 2-constriction of the resistance vessels[1].

Product Specifications

CAS Number

111073-18-8

Product Name Alternative

A-57219; SCH 40054

UNSPSC

12352005

Target

Adrenergic Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Cardiovascular Disease

Smiles

ClC1=C(N)C(Cl)=CC(CC2=NCCN2)=C1.Cl

Molecular Formula

C10H12Cl3N3

Molecular Weight

280.58

References & Citations

[1]DeBernardis JF, et al. A new nasal decongestant, A-57219: a comparison with oxymetazoline. J Pharm Pharmacol. 1987 Sep;39 (9) :760-3.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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