Phospho-MCM2 (S40) Recombinant Rabbit Monoclonal Antibody [JE35-01]
DNA replication licensing factor MCM2 is a protein that in humans is encoded by the MCM2 gene. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication-related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.
Product Specifications
Product Name Alternative
Abbreviation
MCM2, BM28, CCNL1, CDCL1, KIAA0030
Swiss Prot
P49736 Human, P97310 Mouse,
Cellular Locus
Nucleus, Chromosome.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding Ser40 of human MCM2.
Isotype
IgG
Clone
JE35-01
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC, IF-Tissue
Positive Control
HeLa cell lysate, 293T cell lysate, NIH/3T3 cell lysate, C6 cell lysate, HeLa, human tonsil tissue, mouse spleen tissue, rat spleen tissue.
Concentration
1 mg/mL
Dilution
WB: 1:2,000 ;IF-Cell: 1:1,000 ;IHC-P: 1:1,000 ;FC: 1:1,000 ;IF-Tissue: 1:200
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 102 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
CAS Number
9000-83-3
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