Onapristone
Onapristone is a progesterone receptor antagonist, with Kds of 11.6 nM and 11.90 nM for human endometrium and myometrium progesterone receptor in saturation analysis. Onapristone has antitumor activity[1][2].
Product Specifications
CAS Number
96346-61-1
Product Name Alternative
ZK 98299
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Progesterone Receptor
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
C[C@]12[C@](CC[C@]2(O)CCCO)([H])[C@@]3([H])C([C@@H](C4=CC=C(N(C)C)C=C4)C1)=C5C(CC3)=CC(CC5)=O
Molecular Formula
C29H39NO3
Molecular Weight
449.62
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Puri CP, et al. Binding characteristics of progesterone and antiprogestin ZK 98.299 in human endometrial and myometrial cytosol. Biochim Biophys Acta. 1989 May 10;1011 (2-3) :176-82.|[2]Huang Y, et al. Inhibiting Nuclear Phospho-Progesterone Receptor Enhances Antitumor Activity of Onapristone in Uterine Cancer. Mol Cancer Ther. 2018 Feb;17 (2) :464-473.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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