L 377202
L 377202 is a peptide-drug conjugate (PDC). L 377202 consists of Doxorubicin and a prostate-specific antigen (PSA) -hydrolyzable peptide. L 377202 demonstrates strong inhibitory effects on PSA-secreting prostate cancer cells. L 377202 is promising for research of prostate cancer[1].
Product Specifications
CAS Number
207395-85-5
UNSPSC
12352005
Target
Peptide-Drug Conjugates (PDCs) ; Prostaglandin Receptor
Related Pathways
Antibody-drug Conjugate/ADC Related; GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
OC1=C2C([C@H](C[C@@](C(CO)=O)(O)C2)O[C@@]3([H])C[C@@H]([C@H](O)[C@H](C)O3)NC([C@H](CC(C)C)NC([C@H](CO)NC([C@H](CCC(N)=O)NC([C@H](C4CCCCC4)NC([C@H](CO)NC([C@H](C)NC([C@H]5N(C[C@H](O)C5)C(CCCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=C(O)C6=C1C(C7=CC=CC(OC)=C7C6=O)=O
Molecular Formula
C65H89N9O25
Molecular Weight
1396.45
References & Citations
[1]DeFeo-Jones D, et al. A peptide-doxorubicin 'prodrug' activated by prostate-specific antigen selectively kills prostate tumor cells positive for prostate-specific antigen in vivo. Nat Med. 2000 Nov;6 (11) :1248-52.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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