Danitracen
Danitracen (NSC 170955) is an orally active, CNS penetrant serotonin antagonist with antidepressant activity. Danitracen reduces serotonin levels in the cerebrum, cerebellum, medulla and the whole brain. Danitracen exhibits anticataleptic effects in rat catalepsy models. Danitracen can be used for catalepsy and depression research[1][2][3].
Product Specifications
CAS Number
31232-26-5
Product Name Alternative
NSC 170955; WA 335
UNSPSC
12352005
Target
5-HT Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
OC1C2=C(C=CC=C2)/C(C3=CC=CC=C13)=C4CCN(C)CC/4
Molecular Formula
C20H21NO
Molecular Weight
291.39
References & Citations
[1]Maj J, et al. Influence of WA-335, a factor which blocks serotonin receptors, on neuroleptic-induced catalepsy. Arch Immunol Ther Exp (Warsz) . 1976;24 (2) :197-203.|[2]Kaumeier S, et al. WA 335 (danitracen) : a preliminary evaluation of a potential antidepressant compound. A comparative double-blind study with WA 335 and amitriptyline in the treatment of depressive patients. Curr Ther Res Clin Exp. 1977 Jan;21 (1) :108-13.|[3]Maj J, et al. Influence of WA-335, a factor which blocks serotonin receptors, on neuroleptic-induced catalepsy. Arch Immunol Ther Exp (Warsz) . 1976;24 (2) :197-203.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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