Dealanylascamycin

Dealanylascamycin (AT-265) (Compound 2) is a nucleoside antibiotic. AT 265 is a carbonic anhydrase (CA) inhibitor, with Ki values of 167, 65.2, 234, and 143 nM for hCA I, hCA II, hCA IV, and hCA IX respectively. Dealanylascamycin is the active form of Ascamycin (HY-121071) . Dealanylascamycin exhibits broad-spectrum antibacterial activity and is effective against pathogenic bacteria such as Xanthomonas citri (MIC = 0.4 μg/mL) . Dealanylascamycin has high cytotoxicity[1][2].

Product Specifications

CAS Number

[66522-52-9]

Product Name Alternative

AT-265

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Antibiotic; Bacterial; Carbonic Anhydrase

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Infection

Smiles

O[C@H]1[C@@H](O)[C@H](N2C3=NC(Cl)=NC(N)=C3N=C2)O[C@@H]1COS(N)(=O)=O

Molecular Formula

C10H13ClN6O6S

Molecular Weight

380.76

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

References & Citations

[1]Mujumdar P, et al. Synthesis, structure and bioactivity of primary sulfamate-containing natural products. Bioorg Med Chem Lett. 2018 Sep 15;28 (17) :3009-3013.|[2]Isono K, et al. Ascamycin and dealanylascamycin, nucleoside antibiotics from Streptomyces sp. J Antibiot (Tokyo) . 1984 Jun;37 (6) :670-2.