Recombinant Mouse PLA2G1B/PLA2 Protein (His Tag)
Product Specifications
Background
Mouse phospholipase A2 is a secreted protein which belongs to the phospholipase A2 family. Phospholipase A2/PLA2G1B catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. PLA2G1B has been thought to play major role in digestion of glycerophospholipids in nutrients, given its abundance in digestive organs. Since its expression has been observed in non-digestive organs including the lung, spleen, kidney, ovary, retina, brain, and neurons, its function may not limited to digestive role. PLA2G1B are resistant to obesity and diabetes induced by feeding a diabetogenic high-fat/high-carbohydrate diet. PLA2G1B inhibition may be a potentially effective oral therapeutic option for treatment of obesity and diabetes.
Abbreviation
PLA2G1B; PLA2
Synonyms
Group IB phospholipase A2; PLA2-Ib; Phosphatidylcholine 2-acylhydrolase 1B; Phospholipase A2; Pla2; Pla2g1b
UniProt
Q9Z0Y2
Accession Number
Q9Z0Y2
Expression System
HEK293 Cells
Tag
C-His
Sequence
Ala16-Cys146
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
15.6 kDa
Observed Molecular Weight
15 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM HEPES, 150mM NaCl, pH 7.0.
Citation 01
https://www.sciencedirect.com/science/article/pii/S1931312817303943
Species
Mouse
Available Sizes
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