ABC1183 (Standard)
ABC1183 (Standard) is the analytical standard of ABC1183. This product is intended for research and analytical applications. ABC1183 is an orally active selective dual GSK3 and CDK9 inhibitor. ABC1183 inhibits GSK3β, GSK3α and CDK9/cyclin T1 with the IC50 values of 657 nM, 327 nM and 321 nM, respectively. ABC1183 has anti-inflammatory and anti-tumor activities[1].
Product Specifications
CAS Number
1042735-18-1
Target
CDK; GSK-3; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Others; PI3K/Akt/mTOR; Stem Cell/Wnt
Field of Research
Cancer; Inflammation/Immunology
Smiles
N#CC1=CC=C(C(C2=C(N)N=C(NC3=CC=C(C)C=C3)S2)=O)C=C1
Molecular Formula
C18H14N4OS
Molecular Weight
334.39
References & Citations
[1]Randy S Schrecengost, et al. In Vitro and In Vivo Antitumor and Anti-Inflammatory Capabilities of the Novel GSK3 and CDK9 Inhibitor ABC1183. J Pharmacol Exp Ther. 2018 Apr;365 (1) :107-116.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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