ABC1183 (Standard)
ABC1183 (Standard) is the analytical standard of ABC1183 (HY-100950) . This product is intended for research and analytical applications. ABC1183 is an orally active selective dual GSK3 and CDK9 inhibitor. ABC1183 inhibits GSK3β, GSK3α and CDK9/cyclin T1 with the IC50 values of 657 nM, 327 nM and 321 nM, respectively. ABC1183 has anti-inflammatory and anti-tumor activities[1].
Product Specifications
CAS Number
[1042735-18-1]
Target
CDK; GSK-3; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Others; PI3K/Akt/mTOR; Stem Cell/Wnt
Field of Research
Cancer; Inflammation/Immunology
Smiles
N#CC1=CC=C(C(C2=C(N)N=C(NC3=CC=C(C)C=C3)S2)=O)C=C1
Molecular Formula
C18H14N4OS
Molecular Weight
334.39
References & Citations
[1]Randy S Schrecengost, et al. In Vitro and In Vivo Antitumor and Anti-Inflammatory Capabilities of the Novel GSK3 and CDK9 Inhibitor ABC1183. J Pharmacol Exp Ther. 2018 Apr;365 (1) :107-116.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Curated Selection
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