Ambenonium (chloride) (Standard)
Ambenonium (chloride) (Standard) is the analytical standard of Ambenonium (chloride) . This product is intended for research and analytical applications. Ambenonium (WIN 8077) chloride is an orally active and reversible inhibitor of Acetyicholinesterase (AChE) with high affinity. Ambenonium chloride inhibits human AChE with an IC50 value of 0.7 nM (hAChE) [1][2].
Product Specifications
CAS Number
115-79-7
Product Name Alternative
WIN 8077 (chloride) (Standard)
UNSPSC
12352005
Target
Cholinesterase (ChE) ; Reference Standards
Related Pathways
Neuronal Signaling; Others
Field of Research
Others
Smiles
O=C(NCC[N+](CC)(CC)CC1=CC=CC=C1Cl)C(NCC[N+](CC)(CC)CC2=CC=CC=C2Cl)=O.[Cl-].[Cl-]
Molecular Formula
C28H42Cl4N4O2
Molecular Weight
608.47
References & Citations
[1]Hodge AS, et al. Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities. Mol Pharmacol. 1992 May. 41 (5) :937-42.|[2]Komloova M, et al. Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment. Bioorg Med Chem Lett. 2011 Apr 15. 21 (8) :2505-9.|[3]Hazama R, et al. Effects of long-term administration of ambenonium chloride on motor end-plate fine structure and acetylcholine receptor in rat. J Neurol Sci. 1981 Jul. 51 (1) :69-79.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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