UAMC-1110 (Standard)
UAMC-1110 (Standard) is the analytical standard of UAMC-1110. This product is intended for research and analytical applications. UAMC-1110 is a highly potent and selective inhibitor of fibroblast activation protein (FAP) with an IC50 of 3.2 nM. UAMC-1110 also inhibits prolyl oligopeptidase (PREP) with an IC50 of 1.8 μM[1].
Product Specifications
CAS Number
1448440-52-5
Target
FAP; Prolyl Endopeptidase (PREP) ; Reference Standards
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Smiles
O=C(C1=CC=NC2=CC=CC=C12)NCC(N3[C@H](C#N)CC(F)(F)C3)=O
Molecular Formula
C17H14F2N4O2
Molecular Weight
344.32
References & Citations
[1]Jansen K, et al. Extended structure-activity relationship and pharmacokinetic investigation of (4-quinolinoyl) glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP) . J Med Chem. 2014 Apr 10;57 (7) :3053-74.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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