UAMC-1110 (Standard)

UAMC-1110 (Standard) is the analytical standard of UAMC-1110 (HY-100684) . This product is intended for research and analytical applications. UAMC-1110 is a highly potent and selective inhibitor of fibroblast activation protein (FAP) with an IC50 of 3.2 nM. UAMC-1110 also inhibits prolyl oligopeptidase (PREP) with an IC50 of 1.8 μM[1].

Product Specifications

CAS Number

[1448440-52-5]

Target

FAP; Prolyl Endopeptidase (PREP) ; Reference Standards

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; Others

Field of Research

Cancer

Smiles

O=C(C1=CC=NC2=CC=CC=C12)NCC(N3[C@H](C#N)CC(F)(F)C3)=O

Molecular Formula

C17H14F2N4O2

Molecular Weight

344.32

References & Citations

[1]Jansen K, et al. Extended structure-activity relationship and pharmacokinetic investigation of (4-quinolinoyl) glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP) . J Med Chem. 2014 Apr 10;57 (7) :3053-74.