MLi-2 (Standard)

MLi-2 (Standard) is the analytical standard of MLi-2 (HY-100411) . This product is intended for research and analytical applications. MLi-2, a chemical probe, is an orally active and highly selective LRRK2 inhibitor with an IC50 of 0.76 nM. MLi-2 has the potential for Parkinson’s disease[1].

Product Specifications

CAS Number

[1627091-47-7]

Target

LRRK2; Reference Standards

Related Pathways

Autophagy; Others

Field of Research

Neurological Disease

Smiles

C[C@@](C1)([H])O[C@](C)([H])CN1C2=CC(C3=NNC4=CC=C(OC5(C)CC5)C=C43)=NC=N2

Molecular Formula

C21H25N5O2

Molecular Weight

379.46

References & Citations

[1]Fell MJ, et al. MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition. J Pharmacol Exp Ther. 2015 Dec;355 (3) :397-409.