Naph-Se-TMZ
Product Specifications
UNSPSC Description
Naph-Se-TMZ is a PROTAC-like HDAC1 degrader. Naph-Se-TMZ can reduce the total HDAC activity in glioma cells and enhance the inhibitory effect of Temozolomide (HY-17364). Naph-Se-TMZ consists of the target protein ligand (red part) Temozolomide (HY-17364), the DNA-targeting intercalator (blue part) Nitro-Naphthalimide-C2-acylamide (HY-169437) and the molecular linker (black part). At the same time, the active control of the target protein ligand is: Temozolomide-amino hydrochloride (HY-169439), and the DNA targeting intercalator + linker is: NNISC-2 (HY-169438)[1].
Target Antigen
HDAC; PROTACs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics;PROTAC
Applications
Cancer-programmed cell death
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/naph-se-tmz.html
Smiles
[Se]=C(NNC(C1=C2N(C(N(C)N=N2)=O)C=N1)=O)NCCN(C(C3=C4C(C=C(C=C54)[N+]([O-])=O)=CC=C3)=O)C5=O
Molecular Weight
583.38
References & Citations
[1]Sharma S, et al. Synthesis and characterization of a novel Naphthalimide-Selenium based Temozolomide drug conjugate in glioma cells. Bioorg Chem. 2024 Nov 26;154:107998.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-169433/Naph-Se-TMZ-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-169433/
Clinical Information
No Development Reported
Curated Selection
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