TPEN (Standard)
TPEN (Standard) is the analytical standard of TPEN. This product is intended for research and analytical applications. TPEN (TPEDA) is a specific cell-permeable heavy metal chelator. TPEN has a higher affinity for Zn2+, but a lower affinity for Mg2+ and Ca2+. TPEN induces DNA damage and increases intracellular ROS production. TPEN also inhibits cell proliferation and induces apoptosis[1][2][3].
Product Specifications
CAS Number
16858-02-9
Target
Apoptosis; Autophagy; Reactive Oxygen Species (ROS) ; Reference Standards
Related Pathways
Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others
Field of Research
Cancer
Smiles
N(CC1=NC=CC=C1)(CC2=NC=CC=C2)CCN(CC3=NC=CC=C3)CC4=NC=CC=C4
Molecular Formula
C26H28N6
Molecular Weight
424.55
References & Citations
[1]Ohkubo M, et al. Heavy metal chelator TPEN attenuates fura-2 fluorescence changes induced by cadmium, mercury and methylmercury. J Vet Med Sci. 2016 Jun 1;78 (5) :761-7.|[2]Rahal ON, et al. Chk1 and DNA-PK mediate TPEN-induced DNA damage in a ROS dependent manner in human colon cancer cells. Cancer Biol Ther. 2016 Nov;17 (11) :1139-1148.|[3]E Aizenman, et al. Induction of neuronal apoptosis by thiol oxidation: putative role of intracellular zinc release. J Neurochem. 2000 Nov;75 (5) :1878-88.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
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