(1R,2R) -2-PCCA (hydrochloride) (Standard)

(1R,2R) -2-PCCA (hydrochloride) (Standard) is the analytical standard of (1R,2R) -2-PCCA (hydrochloride) (HY-100013A1) . This product is intended for research and analytical applications. (1R,2R) -2-PCCA hydrochloride is a diastereomer of 2-PCCA, and acts as a potent GPR88 receptor agonist, with an EC50 of 3 nM in cell-free assay, and 603 nM in cell assay.

Product Specifications

Target

GPR88; Reference Standards

Related Pathways

GPCR/G Protein; Others

Field of Research

Neurological Disease

Smiles

CCCC1=CC=C(C2=CC=C(N(C[C@@H](N)[C@@H](C)CC)C([C@H]3[C@H](C4=CC=CC=N4)C3)=O)C=C2)C=C1.[H]Cl.[H]Cl

Molecular Formula

C30H39Cl2N3O

Molecular Weight

528.56

References & Citations

[1]Bi, Yingzhi, et al. Modulators of G Protein-Coupled Receptor 88. US 20110251204 A1.|[2]Jin C, et al. Effect of Substitution on the Aniline Moiety of the GPR88 Agonist 2-PCCA: Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies. ACS Chem Neurosci. 2016 Oct 19;7 (10) :1418-1432.|[3]Jin C, et al. Synthesis, pharmacological characterization, and structure-activity relationship studies of small molecular agonists for the orphan GPR88 receptor. ACS Chem Neurosci. 2014 Jul 16;5 (7) :576-87.