Brilaroxazine (hydrochloride)

Brilaroxazine (RP5063) hydrochloride is a modulator of serotonin receptors, exhibiting potential therapeutic activity in the treatment of pulmonary arterial hypertension (PAH) . Brilaroxazine hydrochloride has been shown to limit functional and structural changes associated with PAH, leading to significant improvements in pulmonary hemodynamics and right ventricular hypertrophy. Brilaroxazine hydrochloride also enhances oxygen saturation levels and alleviates elevated pulmonary arterial pressures when used as an adjunct to standard PAH therapies.

Product Specifications

CAS Number

[1708960-04-6]

Product Name Alternative

RP5063 (hydrochloride)

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/brilaroxazine-hydrochloride.html

Smiles

O=C1NC2=CC(OCCCCN3CCN(CC3)C4=C(Cl)C(Cl)=CC=C4)=CC=C2OC1.Cl

Molecular Formula

C22H26Cl3N3O3

Molecular Weight

486.82

References & Citations

[1]Evaluation of the effects of RP5063, a novel, multimodal, serotonin receptor modulator, as single-agent therapy and co-administrated with sildenafil, bosentan, and treprostinil in a monocrotaline-induced pulmonary arterial hypertension rat model