Ufenamate (Standard)

Ufenamate (Standard) is the analytical standard of Ufenamate. This product is intended for research and analytical applications. Ufenamate (Flufenamic acid butyl ester) is an anthranilic acid-based anti-inflammatory drug that can be used in the study of skin diseases such as acute and chronic eczema, contact dermatitis, diaper dermatitis, miliary rashes and atopic dermatitis. Ufenamate has a certain photoprotective effect, reduces the degree of skin erythema and swelling in the photoaging model, downregulates the expression level of COX-2 and can promote the healing of mouse skull defects by secreting BMP2[1][2][3][4].

Product Specifications

CAS Number

67330-25-0

Target

COX; Prostaglandin Receptor; Reference Standards

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Others

Field of Research

Inflammation/Immunology

Smiles

O=C(OCCCC)C1=CC=CC=C1NC2=CC=CC(C(F)(F)F)=C2

Molecular Formula

C18H18F3NO2

Molecular Weight

337.34

References & Citations

[1]Iino H, et al. Penetration of Ufenamate into Intact, Stripped, or Delipidized Skin Using Different Vehicles. Biol Pharm Bull. 2015;38 (10) :1645-8.|[2]Hayato Iino, et al. Penetration of Ufenamate into Intact, Stripped, or Delipidized Skin Using Different Vehicles. Bio Pharm Bull. 2015;38 (10) :1645-8.|[3]Ting Lü, et al. Photoprotective effect of butyl flufenamate ointment on SKH-1 hairless mice. Chinese Journal of Dermatology ; (12) : 711-715, 2013.|[4]Fan Yang, et al. Topical Application of Butyl Flufenamate Ointment Promotes Cranial Defect Healing in Mice by Inducing BMP2 Secretion in Skin Mesenchymal Stem Cells. Cells. 2022 Nov 15;11 (22) :3620.