A 784168
Product Specifications
CAS Number
824982-41-4
Target
TRP/TRPV Channel|||Others
Related Pathways
Membrane transporter/Ion channel|||Others
Bioactivity
A-784168, a potent and orally active inhibitor of vanilloid receptor type 1 (TRPV1), acts on a ligand-gated nonselective cation channel pivotal in integrating pain stimuli including endogenous lipids, capsaicin, heat, and low pH. It demonstrates commendable central nervous system (CNS) penetration upon oral administration [1].
Smiles
C(F)(F)(F)C1=C(N=CC=C1)N2CCC(C(NC3=CC=C(S(C(F)(F)F)(=O)=O)C=C3)=O)=CC2
Molecular Formula
C19H15F6N3O3S
Molecular Weight
479.4
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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