(S) -Sabutoclax
(S) -Sabutoclax ((S) -BI-97C1), an optically pure apogossypol derivative, is pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. (S) -Sabutoclax (Compound II) inhibits the binding of BH3 peptides to Bcl-XL, Bcl-2, Mcl-1, and Bfl-1 with IC50 values of 0.31, 0.32, 0.20, and 0.62 μM, respectively. (S) -Sabutoclax also potently inhibits cell growth of human prostate cancer, lung cancer, and lymphoma cell lines with EC50 values of 0.13, 0.56, and 0.049 μM, respectively. (S) -Sabutoclax can be used for the research of apoptosis-based therapies against cancer[1].
Product Specifications
CAS Number
1228178-73-1
Product Name Alternative
(S) -BI-97C1
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-sabutoclax.html
Purity
98.03
Solubility
DMSO : 30 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
O=C(C1=C(O)C(O)=CC2=C(O)[C@]([C@]3=C(C)C=C4C(C(NC[C@@H](C5=CC=CC=C5)C)=O)=C(O)C(O)=CC4=C3O)=C(C)C=C12)NC[C@@H](C6=CC=CC=C6)C
Molecular Formula
C42H40N2O8S
Molecular Weight
732.84
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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