ERK5-IN-5

ERK5-IN-5 (compound 4a) is an ERK5 kinase inhibitor with anticancer activity. ERK5-IN-5 exhibits good anti-proliferative activity with the IC50 value of 6.23 µg/mL for A549 cells[1].

Product Specifications

CAS Number

[2318792-30-0]

UNSPSC

12352005

Target

ERK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/erk5-in-5.html

Purity

99.05

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N1CC=C(C2=CNC3=NC=CC=C32)CC1)C4=CC=C(Cl)C=C4

Molecular Formula

C19H16ClN3O

Molecular Weight

337.80

References & Citations

[1]Qin Zhang, et al. Design, synthesis and SAR of novel 7-azaindole derivatives as potential Erk5 kinase inhibitor with anticancer activity. Bioorg Med Chem. 2023 Oct 14:95:117503.