RET Mouse Monoclonal Antibody [Clone ID: LBI4H3]
Product Specifications
Background
This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008]
Synonyms
CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET-ELE1; RET51
Gene Name
Ret proto-oncogene
Gene ID
5979
UniProt
P07949
Conjugation
Unconjugated
Related Pathways
Endocytosis, Pathways in cancer, Thyroid cancer
Field of Research
Endocytosis, Pathways in cancer, Thyroid cancer
Concentration
1 mg/ml
Dilution
WB 1:500, IHC 1:150
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome, Protein Kinase, Transmembrane
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
RET
Overview
RET mouse monoclonal antibody, clone LBI4H3
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=5979
Uniprot URL
https://www.uniprot.org/uniprot/P07949
Curated Selection
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