Naxagolide

Naxagolide ((+) -PHNO; Dopazinol) is a potent dopamine D2 (Dopamine Receptor) agonist. Naxagolide has the potential for the research of parkinson's disease (PD) [1][2].

Product Specifications

CAS Number

[88058-88-2]

Product Name Alternative

(+) -PHNO; Dopazinol

UNSPSC

12352005

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/naxagolide.html

Purity

98.85

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

OC1=CC2=C(C=C1)CC[C@]3([H])[C@]2([H])OCCN3CCC

Molecular Formula

C15H21NO2

Molecular Weight

247.33

References & Citations

[1]G E Martin, et al. Pharmacologic profile of a novel potent direct-acting dopamine agonist, (+) -4-propyl-9-hydroxynaphthoxazine [ (+) -PHNO]. J Pharmacol Exp Ther. 1984 Sep;230 (3) :569-76.|[2]E F Domino, et al. Relative potency and efficacy of some dopamine agonists with varying selectivities for D1 and D2 receptors in MPTP-induced hemiparkinsonian monkeys. J Pharmacol Exp Ther. 1993 Jun;265 (3) :1387-91.