PI-1840
Product Specifications
UNSPSC Description
PI-1840 is a potent and selective chymotrypsin-like (CT-L) inhibitor for with an IC50 value of 27 nM. PI-1840 inhibits cell proliferation and arrest cell cycle at G2/M phase. PI-1840 induces apoptosis and induces autophagy. PI-1840 induces the accumulation of proteasome substrates p27, Bax, and IκB-α[1][2].
Target Antigen
Apoptosis; Autophagy; Bcl-2 Family; Caspase; NF-κB; PARP; Proteasome
Type
Reference compound
Related Pathways
Apoptosis;Autophagy;Cell Cycle/DNA Damage;Epigenetics;Metabolic Enzyme/Protease;NF-κB
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PI-1840.html
Purity
98.78
Solubility
DMSO : 100 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL
Smiles
O=C(N(C(C)C)CC1=NC(C2=CC=CN=C2)=NO1)COC3=CC=C(CCC)C=C3
Molecular Weight
394.47
References & Citations
[1]Kazi A, et, al. Discovery of PI-1840, a novel noncovalent and rapidly reversible proteasome inhibitor with anti-tumor activity. J Biol Chem. 2014 Apr 25;289(17):11906-11915.|[2]Chen Y, et, al. Non covalent proteasome inhibitor PI 1840 induces apoptosis and autophagy in osteosarcoma cells. Oncol Rep. 2019 May;41(5):2803-2817.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12286/PI-1840-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12286/PI-1840-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1401223-22-0
Available Sizes
Curated Selection
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