Trabodenoson

Trabodenoson (INO-8875), an adenosine mimetic, is a highly selective Adenosine A1 receptor agonist. Trabodenoson (INO-8875) is used in the study for Primary Open-Angle Glaucoma[1].

Product Specifications

CAS Number

[871108-05-3]

Product Name Alternative

INO-8875

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/trabodenoson.html

Concentration

10mM

Purity

99.97

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@@H](O[C@H](CO[N+]([O-])=O)[C@H]1O)N2C3=NC=NC(NC4CCCC4)=C3N=C2

Molecular Formula

C15H20N6O6

Molecular Weight

380.36

Precautions

H315, H319, H335

References & Citations

[1]Guorong Li, et al. Trabodenoson, an Adenosine Mimetic With A1 Receptor Selectivity Lowers Intraocular Pressure by Increasing Conventional Outflow Facility in Mice. Invest Ophthalmol Vis Sci. 2018 Jan 1;59 (1) :383-392.|[2]Yan Guo, et al. Topical Trabodenoson Is Neuroprotective in a Rodent Model of Anterior Ischemic Optic Neuropathy (rNAION) . Transl Vis Sci Technol. 2019 Dec 20;8 (6) :47.